Trojniar W, Jurkowlaniec E, Ozorowska T
Department of Animal Physiology, University of Gdańsk, Poland.
Acta Neurobiol Exp (Wars). 1990;50(3):81-91.
The effect of electrolytic lesions of varying size within the anterior part of the lateral hypothalamus (LH) on neocortical activity and quantitative sleep-waking relations was studied in male Wistar rats. It was found that extensive LH lesions caused simultaneously an abolishment of cortical desynchronizing reactions and an electroencephalographic insomnia. More restricted damage left the qualitative pattern of cortical EEG unchanged, but still produced substantial reduction in the amount of sleep. Pronounced EEG disturbances coexisted with relatively mild behavioral deficits. It is concluded that a constellation of the LH syndrome symptoms is critically dependent on the variations of lesion parameters.
研究了雄性Wistar大鼠下丘脑外侧区（LH）前部不同大小的电解损伤对新皮层活动及定量睡眠-觉醒关系的影响。结果发现，广泛的LH损伤同时导致皮层去同步反应消失和脑电图失眠。损伤范围较小的情况下，皮层脑电图的定性模式未改变，但睡眠量仍显著减少。明显的脑电图紊乱与相对较轻的行为缺陷并存。结论是，LH综合征症状群严重依赖于损伤参数的变化。
