Institute for Health, Health Care Policy, and Aging Research, Rutgers University, 30 College Ave., New Brunswick, NJ 08901, USA.
Psychiatr Serv. 2011 Mar;62(3):313-6. doi: 10.1176/ps.62.3.pss6203_0313.
The study examined relationships between adherence to bipolar medication and to antiretroviral therapy, measured by medication fills, among patients with diagnoses of bipolar disorder and HIV infection.
A retrospective study was conducted of Medicaid claims data (2001-2004) from eight states, focusing on antiretroviral adherence. The unit of analysis was person-month (N=53,971). The average observation period for the 1,687 patients was 32 months. Analyses controlled for several patient characteristics.
Patients possessed antiretroviral drugs in 72% of the person-months. When a bipolar medication prescription was filled in the prior month, the rate of antiretroviral possession in the subsequent month was 78%, compared with 65% when bipolar medication was not filled in the prior month (p<.001). Odds of antiretroviral possession were 66% higher in months when patients had a prior-month supply of bipolar medication.
Bipolar medication adherence may improve antiretroviral adherence among patients with bipolar disorder and HIV infection.
本研究通过药物配给衡量了双相情感障碍和 HIV 感染患者在服用双相情感障碍药物和抗逆转录病毒药物方面的依从性，分析了两者之间的关系。
对来自八个州的医疗补助计划（2001-2004 年）索赔数据进行了回顾性研究，重点关注抗逆转录病毒药物的依从性。分析的单位是人-月（N=53971）。1687 名患者的平均观察期为 32 个月。分析控制了几个患者特征。
在 72%的人-月中，患者拥有抗逆转录病毒药物。在前一个月开具了双相情感障碍药物处方的情况下，下一个月拥有抗逆转录病毒药物的比例为 78%，而在前一个月没有开具双相情感障碍药物处方的情况下，这一比例为 65%（p<.001）。在前一个月有双相情感障碍药物供应的月份，患者拥有抗逆转录病毒药物的可能性要高出 66%。
双相情感障碍药物的依从性可能会提高双相情感障碍和 HIV 感染患者的抗逆转录病毒药物的依从性。
