Department of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Box 90519, Durham, NC, 27708, USA.
AIDS Behav. 2012 Nov;16(8):2267-71. doi: 10.1007/s10461-012-0203-4.
This study examined HIV transmission risk behavior among 63 patients with bipolar disorder (BD), major depressive disorder, and no mood disorder; half had substance use disorders (SUDs). Patients with BD were more likely than others to report unprotected intercourse with HIV-negative partners and <95 % adherence to antiretroviral medications. In multivariate models, BD and SUD were independent predictors of both risk behaviors. Participants with poorer medication adherence were more likely to have detectable HIV viral loads and unprotected intercourse with HIV-negative partners. Patients with BD deserve careful evaluation and HIV prevention services to reduce HIV transmission risk behaviors.
本研究调查了 63 名双相情感障碍（BD）、重性抑郁障碍和无心境障碍患者以及一半物质使用障碍（SUD）患者的 HIV 传播风险行为。BD 患者与其他患者相比，更有可能报告与 HIV 阴性伴侣发生无保护性行为，以及抗逆转录病毒药物治疗的依从性<95%。在多变量模型中，BD 和 SUD 是这两种风险行为的独立预测因素。药物治疗依从性较差的参与者更有可能出现可检测到的 HIV 病毒载量和与 HIV 阴性伴侣发生无保护性行为。BD 患者需要仔细评估和 HIV 预防服务，以减少 HIV 传播风险行为。
