Padilla-Docal Bárbara, Dorta-Contreras Alberto J, Moreira Juan M, Martini-Robles Luiggi, Muzzio-Aroca Jenny, Alarcón Fernando, Magraner-Tarrau María Esther, Bu-Coifiu-Fanego Raisa
Laboratorio Central de Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Dr. Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, Havana, Cuba.
Am J Trop Med Hyg. 2011 Mar;84(3):406-10. doi: 10.4269/ajtmh.2011.10-0500.
Angiostrongylus cantonensis meningitis was first reported in Cuba in 1981, and it was recently reported in South America. The aim of this paper is to evaluate the intrathecal immunoglobulin synthesis patterns from Cuba's and Ecuador's patients with angiostrongyliasis; 8 Ecuadorian patients from two different outbreaks and 28 Cuban patients were studied. Simultaneous blood and cerebrospinal fluid samples were taken. Immunoglobulin (Ig) A, IgM, IgG, and albumin were quantified by radial immunodiffusion. Corresponding Reibergrams were applied. A three-Ig pattern was the most frequent in the two groups, but IgM was presented in all Ecuadorian young mature patients; however, in the Cuban children, only 12 of 28 patients had intrathecal IgM, but about 90% had an IgA and IgG synthesis at time of later puncture. This indicates that, with a larger amount of parasites ingested, clinical symptoms are more severe, and a higher frequency of intrathecal IgM synthesis could be observed. This is discussed as a similarity with the intrathecal IgM synthesis in African trypanosomiasis.
广州管圆线虫脑膜炎于1981年在古巴首次报道，最近在南美洲也有报道。本文旨在评估古巴和厄瓜多尔广州管圆线虫病患者的鞘内免疫球蛋白合成模式；研究了来自两次不同疫情的8名厄瓜多尔患者和28名古巴患者。同时采集血液和脑脊液样本。通过放射免疫扩散法定量免疫球蛋白（Ig）A、IgM、IgG和白蛋白。应用相应的赖伯格图。两组中最常见的是三免疫球蛋白模式，但所有厄瓜多尔年轻成年患者均出现IgM；然而，在古巴儿童中，28名患者中只有12名有鞘内IgM，但约90%的患者在后期穿刺时出现IgA和IgG合成。这表明，摄入的寄生虫数量越多，临床症状越严重，鞘内IgM合成频率越高。这被讨论为与非洲锥虫病中鞘内IgM合成的相似性。
