厄瓜多尔患者广州管圆线虫脑膜炎的神经免疫学研究结果
Neuroimmunological findings of Angiostrongylus cantonensis meningitis in Ecuadorian patients.
作者信息
Dorta-Contreras Alberto J, Padilla-Docal Barbara, Moreira Juan M, Robles Luiggi Martini, Aroca Jenny Muzzio, Alarcón Fernando, Bu-Coifiu-Fanego Raisa
机构信息
Central Spinal Fluid Laboratory, "Dr. Miguel Enríquez" School of Medical Sciences, Havana University of Medical Sciences, Cuba.
出版信息
Arq Neuropsiquiatr. 2011 Jun;69(3):466-9. doi: 10.1590/s0004-282x2011000400011.
UNLABELLED
Meningitis caused by Angiostrongylus cantonensis has recently been reported in patients resulting from the first outbreaks in subtropical regions of Ecuador.
METHOD
Eight young adult patients from the two outbreaks were studied. IgA, IgM, IgG and albumin in cerebrospinal fluid and serum were quantified and plotted in cerebrospinal fluid/serum quotient diagrams (Reibergrams). The anamnesis on the patients included asking about any consumption of raw snails, symptoms and harm caused.
RESULTS
Mean eosinophilia of 7.5% and 26% in serum and cerebrospinal fluid respectively was observed, as well as a moderate increase in total proteins. The most frequent pattern of intrathecal synthesis was observed in three classes of immunoglobulins. Intrathecal synthesis of IgM was observed in all cases two weeks after the first symptoms appeared.
CONCLUSION
The intrathecal synthesis patterns of eosinophilic meningitis due to Angiostrongylus cantonensis, facilitated by cerebrospinal fluid analysis, were similar to those of previous cases from abroad.
未加标注
最近有报道称，在厄瓜多尔亚热带地区首次爆发疫情后，有患者感染了广州管圆线虫引起的脑膜炎。
方法
对两次疫情中的8名年轻成年患者进行了研究。对脑脊液和血清中的IgA、IgM、IgG和白蛋白进行定量，并绘制在脑脊液/血清商数图（赖伯格图）中。对患者的问诊包括询问是否食用过生蜗牛、症状及造成的损害。
结果
血清和脑脊液中的嗜酸性粒细胞增多症平均分别为7.5%和26%，总蛋白也有中度升高。在三类免疫球蛋白中观察到最常见的鞘内合成模式。在出现最初症状两周后的所有病例中均观察到IgM的鞘内合成。
结论
通过脑脊液分析，广州管圆线虫引起的嗜酸性粒细胞性脑膜炎的鞘内合成模式与国外先前病例相似。
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