Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Int J Obes (Lond). 2011 Dec;35(12):1487-94. doi: 10.1038/ijo.2011.20. Epub 2011 Mar 1.
To test the hypothesis that obesity (increase in fat mass) independently affects the level of adipokines: adiponectin, tumor necrosis factor-α (TNFα) and interleukin (IL)-6.
Publications in the past decade reporting adult plasma adiponectin, leptin, TNFα and/or IL-6 levels were compiled. Mean gender-specific values were extracted from studies that included medical screening to confirm physical health (43 groups, total 4852 subjects). Correlation analysis was conducted between adipokine levels and body mass index (BMI), a widely used estimate of adiposity.
For healthy lean to obese adults of both genders, no significant correlation between plasma adiponectin and BMI was detected. There was also no gender difference in plasma adiponectin level. In contrast, leptin levels showed a positive correlation with BMI in both genders, and women had significantly higher levels of plasma leptin consistent with a higher percentage of body fat. The proinflammatory cytokine TNFα failed to show correlation with BMI. Although IL-6 showed a positive correlation with BMI in women, the obesity-related increase was very limited.
Data analysis based on studies performed on healthy adults did not support the hypothesis that obesity independently affects the plasma level of adiponectin and TNFα. Reported obesity-related changes in plasma adipokine levels may be a consequence of obesity-related metabolic disorders. Future studies are especially needed to understand the homeostasis of adiponectin.
验证肥胖（体脂增加）是否会独立影响脂肪因子（脂联素、肿瘤坏死因子-α（TNFα）和白细胞介素（IL）-6）水平的假说。
收集过去十年中报告成人血浆脂联素、瘦素、TNFα 和/或 IL-6 水平的文献。从通过医学筛查确认身体健康的研究中提取出具有性别特异性的平均值（共 43 组，总计 4852 名受试者）。对脂肪因子水平与体重指数（BMI）进行相关性分析，BMI 是衡量肥胖的常用指标。
对于健康的男女肥胖成年人，血浆脂联素与 BMI 之间无显著相关性。血浆脂联素水平在性别上也没有差异。相比之下，瘦素水平在两性中均与 BMI 呈正相关，且女性的血浆瘦素水平明显更高，这与体脂百分比更高相一致。促炎细胞因子 TNFα 与 BMI 无相关性。尽管 IL-6 在女性中与 BMI 呈正相关，但肥胖相关的增加非常有限。
基于对健康成年人进行的研究进行数据分析，不支持肥胖独立影响血浆脂联素和 TNFα 水平的假说。报告的肥胖相关的血浆脂肪因子水平的变化可能是肥胖相关代谢紊乱的结果。需要进一步研究来了解脂联素的体内平衡。
