损害控制演练。
A damage limitation exercise.
出版信息
Nat Cell Biol. 2011 Mar;13(3):193-5. doi: 10.1038/ncb0311-193.
PMID:21364567
Abstract
Cellular senescence is a potent tumour suppressor mechanism that is often accompanied by activation of dna damage response (DDR) signalling and marked heterochromatinization. Senescence-associated heterochromatin is now shown to limit DDR, thus reducing apoptosis and promoting survival of senescent cells.
摘要
细胞衰老（cellular senescence）是一种强大的肿瘤抑制机制，通常伴随着 DNA 损伤反应（DDR）信号的激活和明显的异染色质化（heterochromatinization）。现在已经表明，衰老相关的异染色质限制了 DDR，从而减少了凋亡（apoptosis）并促进了衰老细胞的存活。
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