光学相干断层扫描在脑血管生理学定量研究中的应用。
Optical coherence tomography for the quantitative study of cerebrovascular physiology.
机构信息
Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
出版信息
J Cereb Blood Flow Metab. 2011 Jun;31(6):1339-45. doi: 10.1038/jcbfm.2011.19. Epub 2011 Mar 2.
Abstract
Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
摘要
多普勒光相干断层扫描（DOCT）和 OCT 血管造影是研究脑血管生理学的新方法。在啮齿动物皮层中，DOCT 血流显示出与脑血流特征一致的特征，包括在非分支血管段和分支点处保持一致。此外，当同时测量时，DOCT 血流值与氢清除血流值相关。这些数据验证了 DOCT 作为一种非侵入性的定量方法，可以在生理范围内测量组织灌注。
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