Schwab M, Schaeffeler E, Zanger U M, Brauch H, Kroemer H K
Dr. Margarete Fischer-Bosch Institut für Klinische Pharmakologie, Universitätsklinikum Tübingen, Auerbachstrasse 112, 70376 Stuttgart.
Dtsch Med Wochenschr. 2011 Mar;136(10):461-7. doi: 10.1055/s-0031-1274528. Epub 2011 Mar 1.
Pharmacogenomics follows the concept of individualized medicine via targeted and tailored therapy for each patient. This is aided by current progress in human genome research that provided the basis to link genetic markers with pathogenesis and progression for the definition of new therapy options. To achieve this it will be necessary to show the validity and clinical utility of pharmacogenomic tests prior to release. The implementation of pharmacogenomics into clinical practise is a momentous future challenge that requires the establishment of interdisciplinary networks and professional organizations.
药物基因组学遵循个体化医疗的理念,通过为每位患者提供靶向和定制化治疗来实现。人类基因组研究的当前进展有助于实现这一点,该进展为将基因标记与发病机制及疾病进展相联系以定义新的治疗选择提供了基础。要实现这一目标,有必要在发布之前证明药物基因组学检测的有效性和临床实用性。将药物基因组学应用于临床实践是未来一项重大挑战,这需要建立跨学科网络和专业组织。