体表心电图：一种检测大鼠显性和隐性心脏病的简单可靠方法。

The surface electrocardiogram: a simple and reliable method for detecting overt and latent heart disease in rats.

Bestetti R B, Oliveira J S

Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

Braz J Med Biol Res. 1990;23(12):1213-22.

Abstract

The following changes may be observed in the resting ECG of Wistar rats having different forms of heart disease: pathological Q wave, QRS deviations, lengthening of both P wave and QRS complex, increased PR interval and J point alterations. 2. The ajmaline test, when applied to rats with myocardial disease but with normal resting ECG, presented the following ECG alterations which were not observed in normal rats: indeterminate axis (QRS axis in the 3rd space), increased PR interval and lengthening of both P wave and QRS complex. 3. When compared with histopathological studies, the ECG changes have a high positive predictive value for detecting underlying myocardial disease. 4. The surface ECG can be a useful tool for detecting myocardial disease in different experimental models of rat heart disease. It can also be used to characterize rat models of heart disease and to evaluate treatment of experimental rat heart disease.

摘要

在患有不同形式心脏病的Wistar大鼠静息心电图中可观察到以下变化：病理性Q波、QRS波群偏移、P波和QRS波群时限延长、PR间期延长以及J点改变。2. 对静息心电图正常但患有心肌病的大鼠进行阿义马林试验时，出现了以下正常大鼠未观察到的心电图变化：电轴不确定（第三肋间QRS电轴）、PR间期延长以及P波和QRS波群时限延长。3. 与组织病理学研究相比，心电图变化对于检测潜在的心肌病具有较高的阳性预测价值。4. 体表心电图可作为检测大鼠心脏病不同实验模型中心肌病的有用工具。它还可用于对大鼠心脏病模型进行特征描述，并评估实验性大鼠心脏病的治疗效果。