静息心电图用于表征大鼠急性恰加斯心脏病的效用。

The usefulness of the resting electrocardiogram for characterizing acute Chagas' heart disease in the rat.

作者信息

Bestetti R B, Baroldi G, Sales-Neto V N, Soares E G, Oliveira J S

机构信息

Department of Pathology, Faculty of Medicine, Ribeirão Preto, Brazil.

出版信息

Int J Cardiol. 1988 Mar;18(3):305-15. doi: 10.1016/0167-5273(88)90049-6.

DOI:10.1016/0167-5273(88)90049-6

PMID:3360518

Abstract

The present experiment was undertaken to characterize the resting electrocardiogram of rats in the acute stage of experimental T. cruzi infection. One-hundred-and-eighty-seven newly-weaned male albino rats were infected intraperitoneally with 1000 parasites/g body weight. Thirty-two similar but non-infected rats served as controls. Groups of eight randomly chosen rats were killed on day 8, and on days 15, 18, 22, 25 and 29 after infection. Groups of 8 control rats were killed on days 8, 15 and 22. Electrocardiographic changes were observed in 25 of 48 (52%) infected rats. P wave abnormalities indicating atrial chamber dilatation, QRS axis deviation, QRS complex changes compatible with left ventricular hypertrophy or myocardial damage, increased PR interval and ventricular repolarization alteration were detected in 24, 27, 18, 10, and 6% of infected rats, respectively. A mononuclear cell infiltrate and pseudocysts of amastigote forms of T. cruzi were found in 91, and 56% of infected animals, respectively. The sensitivity and the positive predictive value of the electrocardiographic changes were 66, 91, and 96%, respectively. Thus, the resting electrocardiogram is a reliable method for detecting myocardial lesions in the rat with acute Chagas' heart disease.

摘要

本实验旨在对实验性克氏锥虫感染急性期大鼠的静息心电图进行特征描述。187只刚断奶的雄性白化大鼠经腹腔注射1000个寄生虫/克体重。32只相似但未感染的大鼠作为对照。在感染后第8天以及第15、18、22、25和29天，每组随机选取8只大鼠处死。在第8、15和22天处死每组8只对照大鼠。在48只感染大鼠中有25只（52%）观察到心电图变化。分别在24%、27%、18%、10%和6%的感染大鼠中检测到提示心房扩张的P波异常、QRS轴偏移、与左心室肥厚或心肌损伤相符的QRS波群变化、PR间期延长以及心室复极改变。分别在91%和56%的感染动物中发现克氏锥虫无鞭毛体形式的单核细胞浸润和假囊肿。心电图变化的敏感性和阳性预测值分别为66%、91%和96%。因此，静息心电图是检测急性恰加斯心脏病大鼠心肌病变的可靠方法。