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[自闭症谱系障碍与μ节律。一种新的神经生理学观点]

[Autism spectrum disorders and mu rhythm. A new neurophysiological view].

作者信息

Palau-Baduell Montserrat, Valls-Santasusana Antonio, Salvadó-Salvadó Berta

机构信息

Servicio de Neurofisiología, Hospital Universitari del Mar, Passeig Maritim 25-29, Barcelona, Spain.

出版信息

Rev Neurol. 2011 Mar 1;52 Suppl 1:S141-6.

Abstract

Electroencephalographic studies of subjects with autism spectrum disorders (ASD) provide evidences of brain functional aspects in this pathology. Mu rhythm can be reactive in normal population (mu suppression) to both self-movements and to movements performed by others. These reactivities are considered to be related to mirror neurons activity. Subjects with ASD show significant mu suppression to self-movements but they fail to react to the movements performed by others. These findings support the hypothesis of a dysfunctional mirror neurons system in individuals with ASD. Moreover, dysfunction of mirror neurons would be related to social and communicative impairments, cognitive deficits and impairment imitation skills associated with ASD.

摘要

对自闭症谱系障碍(ASD)患者的脑电图研究为这种病理状态下的大脑功能方面提供了证据。在正常人群中,μ节律对自身运动和他人执行的运动均有反应(μ抑制)。这些反应性被认为与镜像神经元活动有关。患有ASD的患者对自身运动表现出显著的μ抑制,但对他人执行的运动没有反应。这些发现支持了ASD患者镜像神经元系统功能失调的假说。此外,镜像神经元功能失调与ASD相关的社交和沟通障碍、认知缺陷及模仿技能受损有关。

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