Simić Dušica, Bogićević Dragana, Milojević Irina, Budić Ivana, Marković Marija
Srp Arh Celok Lek. 2010 Nov-Dec;138(11-12):768-76. doi: 10.2298/sarh1012768s.
Children with inherited neuromuscular diseases often require anaesthesia for diagnostic or therapy procedures. These patients have an increased risk of perioperative complications due to the nature of the disease and medications administered during anaesthesia. Many anaesthetics and muscle relaxants can aggravate the underlying disease and trigger life-threatening reactions (cardiorespiratory complications, malignant hyperthermia). Besides, the neuromuscular disorders are associated with atypical and undesirable responses to drugs used during anaesthesia and the perioperative period. The paper presents pathophysiological basis of inherited/genetic neuromuscular diseases and specific anaesthesiological problems. The recommendations are suggested with the aim to make the perioperative course in children optimally safe.
患有遗传性神经肌肉疾病的儿童在进行诊断或治疗程序时通常需要麻醉。由于疾病的性质以及麻醉期间使用的药物，这些患者围手术期并发症的风险增加。许多麻醉剂和肌肉松弛剂会加重潜在疾病并引发危及生命的反应（心肺并发症、恶性高热）。此外，神经肌肉疾病与麻醉和围手术期使用的药物的非典型和不良反应有关。本文介绍了遗传性/基因性神经肌肉疾病的病理生理基础以及特定的麻醉问题。提出这些建议的目的是使儿童围手术期过程尽可能安全。
