结核分枝杆菌基因分型：在流行病学研究中的应用。
Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies.
机构信息
University of California, San Francisco, Francis J Curry National Tuberculosis Center, Division of Pulmonary & Critical Care Medicine, San Francisco General Hospital, 1001 Potrero Avenue, Building 100, Room 109, Mail box 0841, San Francisco, CA 94110-0111, USA.
出版信息
Future Microbiol. 2011 Feb;6(2):203-16. doi: 10.2217/fmb.10.165.
Abstract
Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies including the use of whole-genome sequencing technology. We also review the public health application of molecular epidemiologic tools.
摘要
基因分型用于在社区中追踪结核分枝杆菌的特定分离株。它已成功用于流行病学研究（称为“分子流行病学”），以研究结核病的传播动态。在本文中，我们回顾了分子流行病学研究中使用的遗传标记，包括全基因组测序技术的使用。我们还回顾了分子流行病学工具在公共卫生中的应用。
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