National Reference Centre for Mycobacteria (CNR-MyRMA), Laboratoire de Bactériologie-Hygiène, UPMC, ER5, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Clin Microbiol Infect. 2011 Jun;17(6):800-5. doi: 10.1111/j.1469-0691.2011.03577.x.
Genotyping of Mycobacterium tuberculosis has been extensively used for investigating epidemics of multidrug-resistant strains of M. tuberculosis, in order to identify the factors involved in the transmission of such strains and determine effective control programmes to limit their expansion at both the individual and population levels. Here, we review the methods currently used to study the molecular epidemiology of multidrug-resistant M. tuberculosis strains, and the insights provided by these techniques regarding global trends and the transmission dynamics of multidrug-resistant tuberculosis at a world scale.
结核分枝杆菌的基因分型已被广泛用于研究耐多药结核分枝杆菌菌株的流行情况，以确定这些菌株传播所涉及的因素，并制定有效的控制方案，以限制其在个体和人群层面的扩散。在此，我们综述了目前用于研究耐多药结核分枝杆菌菌株分子流行病学的方法，以及这些技术提供的关于全球范围内耐多药结核病的趋势和传播动态的见解。
