甲型肝炎在法国一个接种中心移民人群中的血清流行率。

Hepatitis A seroprevalence in a population of immigrants at a French vaccination center.

机构信息

Institut Pasteur de Paris, Centre Médical, Paris, France.

出版信息

J Travel Med. 2011 Mar-Apr;18(2):126-9. doi: 10.1111/j.1708-8305.2010.00495.x. Epub 2011 Feb 7.

DOI:10.1111/j.1708-8305.2010.00495.x

PMID:21366797

Abstract

BACKGROUND

Hepatitis A vaccination is recommended to people traveling to countries where the disease is endemic. Until recently, people originating from developing countries were considered to be "naturally" immunized. Because of improving socioeconomic conditions, hepatitis A incidence has decreased in most previously highly endemic countries during the last three decades, especially in the younger age groups.

METHODS

We analyzed hepatitis A seroprevalence of 989 travelers who had been born and lived at least 1 year in a developing country, wanted to travel to a hepatitis A endemic area, and consulted at the vaccination center of the Institut Pasteur of Paris between September 1, 2008 and February 28, 2010.

RESULTS

Hepatitis A serology results were available for 646 subjects. Overall seroprevalence was 82.4%. A total of 90, 82.6, 81.2, 68.4, 56.9, and 50% of people of sub-Saharan African, Near and Middle Eastern, North African, Asian, Latin American, and Eastern European origin had hepatitis A antibodies, respectively. The difference in seroprevalence according to the continent of origin, age, and length of stay in an endemic country was significant (p < 0.0001). More than 75% of seronegatives and less than 50% of seropositives were younger than 36 years. Almost three quarters of the positive group (while less than half of the negative group) lived longer than 18 years in a developing country. Multivariate analysis showed that seroprevalence increases with age, length of stay in a country at risk, and varies significantly from one continent to another.

CONCLUSION

We recommend extending serologic confirmation of immigrants' hepatitis A immunity. If time is lacking, vaccination should be considered.

摘要

背景

甲型肝炎疫苗接种推荐给前往疾病流行地区的人群。直到最近，人们认为来自发展中国家的人是“自然”免疫的。由于社会经济条件的改善，甲型肝炎的发病率在过去三十年中在大多数以前高度流行的国家都有所下降，尤其是在年轻人群中。

方法

我们分析了 989 名旅行者的甲型肝炎血清学患病率，这些旅行者出生并至少在发展中国家生活了 1 年，他们想去甲型肝炎流行地区旅行，并于 2008 年 9 月 1 日至 2010 年 2 月 28 日在巴黎巴斯德研究所接种中心咨询。

结果

共有 646 名旅行者的甲型肝炎血清学结果可用。总体血清阳性率为 82.4%。来自撒哈拉以南非洲、近东和中东、北非、亚洲、拉丁美洲和东欧的旅行者中，分别有 90%、82.6%、81.2%、68.4%、56.9%和 50%的人具有甲型肝炎抗体。根据原籍大陆、年龄和在流行地区的逗留时间，血清阳性率存在显著差异（p < 0.0001）。75%以上的血清阴性者和不到 50%的血清阳性者年龄小于 36 岁。近四分之三的阳性组（而不到一半的阴性组）在发展中国家生活的时间超过 18 年。多变量分析表明，血清阳性率随年龄、在高危国家的逗留时间而增加，且在不同大陆之间差异显著。