Department of Digestive Disease, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, Shandong 250033, PR China.
Pathol Res Pract. 2011 Mar 15;207(3):169-73. doi: 10.1016/j.prp.2010.12.009. Epub 2011 Mar 1.
The aim of this study was to investigate the expression of Nrf2 and IGF-1 in benign, premalignant, and malignant gastric lesions, and to explore the role of Nrf2 and IGF-1 in gastric carcinoma carcinogenesis. Nrf2 and IGF-1 expression was detected in normal gastric mucosa, hyperplastic polyp, intraepithelial neoplasia, and adenocarcinoma by immunohistochemistry. There was no expression of Nrf2 and IGF-1 in normal gastric mucous membrane. With the elevation of Nrf2, IGF-1 expression, their co-expressions were highly elevated from benign proliferative lesions to malignant lesions. There were significant differences between hyperplastic polyps, intraepithelial neoplasias, and adenocarcinoma (hyperplastic polys vs. intraepithelial neoplasia: P=0.012; hyperplastic polyps vs. adenocarcinoma: P=0.023; and intraepithelial neoplasia vs. adenocarcinoma: P=0.027; hyperplastic polyps vs. adenocarcinoma: P=0.0000, respectively). Nrf2 expression and IGF-1 expression were correlated positively (r=0.337, P=0.037). The increased expression of Nrf2 and IGF-1 may be related to gastric carcinogenesis. Elevated Nrf2 and IGF-1 may play important roles in promoting tumor progression.
本研究旨在探讨 Nrf2 和 IGF-1 在良性、癌前和恶性胃病变中的表达，并探讨 Nrf2 和 IGF-1 在胃癌发生中的作用。采用免疫组织化学法检测正常胃黏膜、增生性息肉、上皮内瘤变和腺癌中 Nrf2 和 IGF-1 的表达。正常胃黏膜无 Nrf2 和 IGF-1 表达。随着 Nrf2 的升高，IGF-1 的表达及其共表达从良性增生性病变到恶性病变显著升高。增生性息肉、上皮内瘤变和腺癌之间有显著差异（增生性息肉与上皮内瘤变：P=0.012；增生性息肉与腺癌：P=0.023；上皮内瘤变与腺癌：P=0.027；增生性息肉与腺癌：P=0.0000，分别）。Nrf2 表达与 IGF-1 表达呈正相关（r=0.337，P=0.037）。Nrf2 和 IGF-1 的表达增加可能与胃癌的发生有关。Nrf2 和 IGF-1 的升高可能在促进肿瘤进展中发挥重要作用。
