Genome-wide association studies of alcohol intake--a promising cocktail?
作者信息
Agrawal Arpana, Freedman Neal D, Bierut Laura J
出版信息
Am J Clin Nutr. 2011 Apr;93(4):681-3. doi: 10.3945/ajcn.111.012641. Epub 2011 Mar 2.
Abstract
摘要
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Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.全基因组关联研究鉴定出与韩国男性饮酒相关的遗传位点。
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Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.基于单体型的四个独立人群中酒精代谢基因与酒精依赖相关性的研究。
Alcohol Clin Exp Res. 2011 Feb;35(2):304-16. doi: 10.1111/j.1530-0277.2010.01346.x. Epub 2010 Nov 17.
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A genome-wide association study of alcohol dependence.一项关于酒精依赖的全基因组关联研究。
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5082-7. doi: 10.1073/pnas.0911109107. Epub 2010 Mar 2.
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Genome-wide association study of alcohol dependence implicates a region on chromosome 11.全基因组关联研究提示染色体 11 上的一个区域与酒精依赖有关。
Alcohol Clin Exp Res. 2010 May;34(5):840-52. doi: 10.1111/j.1530-0277.2010.01156.x. Epub 2010 Mar 1.
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Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms.有证据表明，首次饮酒年龄与 DSM-IV 酒精依赖症状的遗传影响之间存在相互作用。
Alcohol Clin Exp Res. 2009 Dec;33(12):2047-56. doi: 10.1111/j.1530-0277.2009.01044.x. Epub 2009 Sep 17.
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Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.乙醇脱氢酶1B（ADH1B）和乙醛脱氢酶2（ALDH2）中的功能变异与酒精和吸烟协同作用，会增加患食管癌风险。
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