Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-1103, USA.
Am J Clin Nutr. 2011 May;93(5):963-7. doi: 10.3945/ajcn.110.006270. Epub 2011 Mar 2.
A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity.
We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals.
In study 1, nonobese [body mass index (BMI; in kg/m(2)) <30] and obese (BMI ≥30) adults swallowed wireless core temperature-sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18-25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis.
Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P < 0.0001).
Obesity is not generally associated with a reduced core body temperature. It may be necessary to study individuals with function-altering mutations in core temperature-regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500.
核心体温设定点较低被认为是人类易患肥胖的一个潜在因素。
我们检验了肥胖者核心体温较体重正常者低的假说。
在研究 1 中，非肥胖者（体重指数[BMI；kg/m(2)]<30）和肥胖者（BMI≥30）吞下无线核心温度感应胶囊，我们连续 24 h 测量核心体温。在研究 2 中，正常体重（BMI 为 18-25）和肥胖者吞下温度感应胶囊，连续 48 h 测量核心体温并记录活动日志。我们构建了每日、24 h 核心体温曲线进行分析。
35 名非肥胖者和 46 名肥胖者的平均（±SE）日核心体温无显著差异（36.92±0.03°C 与 36.89±0.03°C；P=0.44）。11 名正常体重者和 19 名肥胖者的核心体温 24 h 曲线无显著差异（P=0.274）。女性的核心体温平均比男性高约 0.23°C（36.99±0.03°C 与 36.76±0.03°C；P<0.0001）。
肥胖一般与核心体温降低无关。可能需要研究核心体温调节基因功能改变的个体，以确定核心体温设定点的差异是否影响人体体重的调节。这些试验在 clinicaltrials.gov 上注册为 NCT00428987 和 NCT00266500。
