University of Virginia Health System, Charlottesville, VA, USA.
J Am Acad Orthop Surg. 2011 Mar;19(3):134-42. doi: 10.5435/00124635-201103000-00002.
Tendon injuries range from acute traumatic ruptures and lacerations to chronic overuse injuries, such as tendinosis. Even with improved nonsurgical, surgical, and rehabilitation techniques, outcomes following tendon repair are inconsistent. Primary repair remains the standard of care. However, repaired tendon tissue rarely achieves functionality equal to that of the preinjured state. Poor results have been linked to alterations in cellular organization within the tendon that occur at the time of injury and throughout the early stages of healing. Enhanced understanding of the biology of tendon healing is needed to improve management and outcomes. The use of growth factors and mesenchymal stem cells and the development of biocompatible scaffolds could result in enhanced tendon healing and regeneration. Recent advances in tendon bioengineering may lead to improved management following tendon injury.
肌腱损伤的范围包括急性创伤性断裂和撕裂，以及慢性过度使用损伤，如肌腱病。即使采用了改进的非手术、手术和康复技术，肌腱修复后的结果仍然不一致。原发性修复仍然是护理标准。然而，修复后的肌腱组织很少能达到与受伤前相同的功能。不良结果与受伤时和愈合早期肌腱内细胞组织的改变有关。需要增强对肌腱愈合生物学的理解，以改善管理和结果。生长因子和间充质干细胞的应用以及生物相容性支架的开发可能会导致肌腱愈合和再生的增强。肌腱生物工程学的最新进展可能会改善肌腱损伤后的管理。
