Faculté de médecine, Laboratoire de biologie moléculaire parasitaire et fongique, Sfax, Tunisie.
Mycopathologia. 2011 Aug;172(2):83-93. doi: 10.1007/s11046-011-9406-x. Epub 2011 Mar 3.
Aspergillus flavus is the second most important Aspergillus species causing human infections. The importance of this fungus increases in regions with a dry and hot climate. Small phylogenetic studies in Aspergillus flavus indicate that the morphological species contains several genetically isolated species. Different genotyping methods have been developed and employed in order to better understand the genetic and epidemiological relationships between environmental and clinical isolates. Understanding pathogen distribution and relatedness is essential for determining the epidemiology of nosocomial infections and aiding in the design of rational pathogen control methods. Typing techniques can also give us a deeper understanding of the colonization pattern in patients. Most of these studies focused on Aspergillus fumigatus because it is medically the most isolated species. To date, there has not been any publication exclusively reviewing the molecular typing techniques for Aspergillus flavus in the literature. This article reviews all these different available methods for this organism.
黄曲霉是第二重要的曲霉属物种，可引起人类感染。在干燥和炎热气候的地区，这种真菌的重要性增加。黄曲霉的小型系统发育研究表明，形态物种包含几个遗传上隔离的物种。已经开发并采用了不同的基因分型方法，以便更好地理解环境和临床分离物之间的遗传和流行病学关系。了解病原体的分布和相关性对于确定医院感染的流行病学以及帮助设计合理的病原体控制方法至关重要。分型技术还可以使我们更深入地了解患者的定植模式。这些研究大多集中在烟曲霉上，因为它是医学上分离最多的物种。迄今为止，文献中尚无专门针对黄曲霉的分子分型技术的出版物。本文综述了该生物的所有这些不同的可用方法。
