Addiction. 2011 Apr;106(4):687-8. doi: 10.1111/j.1360-0443.2011.03374.x.
Methadone has been linked to cardiac arrhythmia. (R)-methadone appears to confer a lower risk of QT interval prolongation, resulting in debate over how best to treat patients needing this medication. A discussion of salient aspects of selecting therapy for opioid dependence and pain management and decision-making regarding methadone formulation follows.
美沙酮可引起心律失常。(R)-美沙酮似乎可降低 QT 间期延长的风险，这引发了人们对如何最好地治疗需要这种药物的患者的争论。以下是关于选择阿片类药物依赖和疼痛管理治疗方案的重要方面以及美沙酮制剂决策的讨论。
