巴西东南部 HIV-1 感染人群中的结核分枝杆菌。

Mycobacterium tuberculosis in a HIV-1-infected population from Southeastern Brazil in the HAART era.

机构信息

Adolfo Lutz Institute -Regional Laboratory from São José do Rio Preto, São Paulo, SP, Brazil.

出版信息

Trop Med Int Health. 2011 Jan;16(1):67-73. doi: 10.1111/j.1365-3156.2010.02681.x.

DOI:10.1111/j.1365-3156.2010.02681.x

PMID:21371209

Abstract

OBJECTIVE

To evaluate retrospectively the microbiological profile of Mycobacterium species isolated from HIV-infected patients attending the HIV/TB reference health care units in São José do Rio Preto, Brazil.

METHOD

Retrospective evaluation of all HIV-1 positive patients whose IAL-SJRP laboratorial analysis was positive for Mycobacterium sp. after diagnosis of HIV Infection, from January 2000 to December 2006.

RESULTS

Of 198 patients, acid-fast staining detected mycobacteria early in 41%. Culture revealed 52.5% to be infected with Mycobacterium tuberculosis (MT). 42.4% had non-tuberculous mycobacteria (NTM) and 5.1% had MT/NTM positive cultures. Eleven per cent of MT strains were resistant to at least one of the antimycobacterial drugs and 3.1% were multidrug resistant. 39.4% of isolated mycobacteria were NTM species.

CONCLUSION

Our data may serve as a starting point for further comparisons with other Brazilian regions and other developing countries. The data may provide important clues to the future understanding, prevention and control of such co-infections around the world.

摘要

目的

回顾性评估巴西圣若泽-里波雷托 HIV/TB 参考医疗单位收治的 HIV 感染患者中分离出的分枝杆菌属的微生物特征。

方法

对 2000 年 1 月至 2006 年 12 月间，经 IAL-SJRP 实验室分析诊断为 HIV 感染后其 IAL-SJRP 实验室分析呈分枝杆菌阳性的所有 HIV-1 阳性患者进行回顾性评估。

结果

在 198 例患者中，41%的患者早期经酸染色法检测到分枝杆菌。培养结果显示 52.5%的患者感染结核分枝杆菌（MT）。42.4%的患者为非结核分枝杆菌（NTM），5.1%的患者 MT/NTM 培养阳性。11%的 MT 株对至少一种抗分枝杆菌药物具有耐药性，3.1%的 MT 株为耐多药。39.4%分离出的分枝杆菌为 NTM 种。