Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
Biochem Biophys Res Commun. 2011 Apr 1;407(1):129-34. doi: 10.1016/j.bbrc.2011.02.124. Epub 2011 Mar 1.
The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.
前列腺癌的进展与雄激素剥夺条件下细胞周期阻滞和细胞凋亡的逃逸有关。在这里，我们发现香叶醇，一种天然的单萜，在使用 PC-3 前列腺癌细胞的培养细胞和肿瘤移植小鼠中诱导细胞周期阻滞和细胞凋亡。香叶醇在体外和体内调节 PC-3 细胞中各种细胞周期调节剂和 Bcl-2 家族蛋白的表达。此外，我们表明，亚最佳剂量的香叶醇和多西他赛的组合可显著抑制培养细胞和肿瘤异种移植小鼠中的前列腺癌生长。因此，我们的研究结果为揭示细胞周期阻滞和细胞凋亡逃逸的机制以及开发针对前列腺癌的治疗策略提供了新的思路。
