School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Molecules. 2021 Feb 10;26(4):933. doi: 10.3390/molecules26040933.
Cancer is a major factor threatening human health and life safety, and there is a lack of safe and effective therapeutic drugs. Intervention and prevention in premalignant process are effective ways to reverse carcinogenesis and prevent cancer from occurring. Plant natural products are rich in sources and are a promising source for cancer chemoprevention. This article reviews the chemopreventive effects of natural products, especially focused on polyphenols, flavonoids, monoterpene and triterpenoids, sulfur compounds, and cellulose. Meanwhile, the main mechanisms include induction of apoptosis, antiproliferation and inhibition of metastasis are briefly summarized. In conclusion, this article provides evidence for natural products remaining a prominent source of cancer chemoprevention.
癌症是严重威胁人类健康和生命安全的重大因素，目前缺乏安全有效的治疗药物。在癌前病变过程中进行干预和预防是逆转癌变、防止癌症发生的有效途径。植物天然产物来源丰富，是癌症化学预防的有前途的来源。本文综述了天然产物的化学预防作用，特别是多酚、类黄酮、单萜和三萜、含硫化合物和纤维素，同时简要总结了诱导细胞凋亡、抗增殖和抑制转移等主要作用机制。总之，本文为天然产物作为癌症化学预防的突出来源提供了依据。
