脑 SPECT 的应用。

Applications of cerebral SPECT.

机构信息

Department of Neuroradiology, Institute of Neurological Sciences, Glasgow, UK.

出版信息

Clin Radiol. 2011 Jul;66(7):651-61. doi: 10.1016/j.crad.2010.12.015. Epub 2011 Mar 2.

DOI:10.1016/j.crad.2010.12.015

Abstract

Single-photon emission computed tomography (SPECT) can provide three-dimensional functional images of the brain following the injection of one of a series of radiopharmaceuticals that crosses the blood--brain barrier and distributes according to cerebral perfusion, neurotransmitter, or cell density. Applications include differentiating between the dementias, evaluating cerebrovascular disease, preoperative localization of epileptogenic foci, diagnosing movement disorders, and evaluation of intracerebral tumours, while also proving a useful research tool. Unlike positronemission tomography (PET), SPECT imaging is widely available and can be performed in any department that has access to a rotating gamma camera. The purpose of this review is to demonstrate the utility of cerebral SPECT and increase awareness of its role in the investigation of neurological and psychiatric disorders.

摘要

单光子发射计算机断层扫描（SPECT）可以在注射一系列放射性药物后提供大脑的三维功能图像，这些放射性药物可以穿过血脑屏障，并根据脑灌注、神经递质或细胞密度分布。其应用包括区分痴呆症、评估脑血管疾病、癫痫灶术前定位、诊断运动障碍以及评估颅内肿瘤，同时也证明是一种有用的研究工具。与正电子发射断层扫描（PET）不同，SPECT 成像广泛可用，并且可以在任何可以使用旋转伽马相机的部门进行。本综述的目的是展示脑 SPECT 的实用性，并提高对其在神经和精神疾病研究中的作用的认识。