尽管在结节乳头核中存在路易体和路易神经突的堆积，帕金森病患者的神经元组氨酸产生仍保持不变。

Neuronal histamine production remains unaltered in Parkinson's disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus.

机构信息

Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Neurobiol Aging. 2012 Jul;33(7):1343-4. doi: 10.1016/j.neurobiolaging.2011.01.004. Epub 2011 Mar 2.

DOI:10.1016/j.neurobiolaging.2011.01.004

PMID:21371786

Abstract

Neuronal histamine production in the hypothalamic tuberomamillary nucleus (TMN) was hypothesized to change significantly in Parkinson's disease (PD) in relation to the accumulation of Lewy bodies/Lewy neurites (LBs/LNs). We measured the messenger ribonucleic acid (mRNA) levels of histidine decarboxylase (HDC), the key enzyme of histamine production, and the amount of LBs/LNs in the TMN by quantitative in situ hybridization and immunocytochemistry in postmortem human brain material of clinical PD (CPD), preclinical PD, and control subjects. No significant difference of histidine decarboxylase mRNA levels was observed among different clinical or Braak-PD stages, in spite of the strong accumulation of LBs/LNs in the TMN of clinical PD patients. We conclude that neuronal histamine production remains largely unaltered in PD despite the abundant LB/LN accumulation in the TMN.

摘要

人们推测，帕金森病（PD）患者下丘脑结节乳头核（TMN）中的神经元组胺产生会发生显著变化，这与路易体/路易神经突（LB/LN）的积累有关。我们通过定量原位杂交和免疫细胞化学方法，在临床帕金森病（CPD）、临床前 PD 和对照受试者的死后人脑组织中测量了 TMN 中组胺产生的关键酶组氨酸脱羧酶（HDC）的信使核糖核酸（mRNA）水平和 LB/LN 的数量。尽管临床 PD 患者 TMN 中 LB/LN 大量堆积，但不同临床或 Braak-PD 阶段的组氨酸脱羧酶 mRNA 水平无显著差异。我们的结论是，尽管 TMN 中有大量 LB/LN 堆积，但 PD 患者的神经元组胺产生仍基本保持不变。