帕金森病和偶然路易体病中的周围路易体病理学：4 个病例。

Peripheral Lewy body pathology in Parkinson's disease and incidental Lewy body disease: four cases.

机构信息

Clinical Neuroanatomy (Center for Clinical Research, Department of Neurology), University of Ulm, 89081 Ulm, Germany.

出版信息

J Neurol Sci. 2011 Nov 15;310(1-2):100-6. doi: 10.1016/j.jns.2011.06.003.

DOI:10.1016/j.jns.2011.06.003

Abstract

The accumulation of Lewy pathology (LP) within autonomic nervous system tissues has received increased attention recently as a possible induction site for Lewy neurodegeneration and a possible source of biopsy material for biomarkers of early Parkinson's disease (PD). Here, we describe LP accumulation within various tissues involving peripheral autonomic nervous system neurons in three PD cases and one case of incidental Lewy body disease. Findings highlight the value of examining pathology within functional neuroanatomical systems and particularly the importance of Lewy neurites (LNs) in the pathophysiology of PD.

摘要

最近，人们越来越关注自主神经系统组织中路易体病理学（LP）的积累，认为其可能是路易体神经退行性变的诱导部位，也是帕金森病（PD）早期生物标志物活检材料的可能来源。在这里，我们描述了 3 例 PD 病例和 1 例偶发路易体病病例中涉及周围自主神经系统神经元的各种组织中 LP 的积累。这些发现强调了在功能神经解剖系统中检查病理学的价值，特别是路易神经突（LNs）在 PD 病理生理学中的重要性。