Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.
Cancer Lett. 2011 May 1;304(1):1-7. doi: 10.1016/j.canlet.2010.12.023. Epub 2011 Mar 2.
AGR2 has evolutionarily conserved roles in development and tissue regeneration and is linked with several human cancers. The exact functions and regulation of AGR2 are poorly understood, but current data identify AGR2 as a clinically relevant factor that modulates the behavior and response of hormone-dependent cancers (breast, prostate) and hormone-independent cancers (colorectal, pancreatic, esophageal and other common cancers). AGR2 protein expression induces metastasis, acts as a p53 tumor suppressor inhibitor and survival factor, participates directly in neoplastic transformation and is involved in drug resistance. Thus, AGR2 is an important tumor biomarker and negative prognostic factor potentially exploitable in clinical practice.
AGR2 在发育和组织再生中具有进化保守的作用，与多种人类癌症有关。AGR2 的确切功能和调节机制尚不清楚，但目前的数据表明，AGR2 是一个具有临床相关性的因子，可调节激素依赖性癌症（乳腺癌、前列腺癌）和激素非依赖性癌症（结直肠癌、胰腺癌、食管癌和其他常见癌症）的行为和反应。AGR2 蛋白表达可诱导转移，作为 p53 肿瘤抑制因子抑制剂和生存因子发挥作用，直接参与肿瘤转化，并与耐药性有关。因此，AGR2 是一个重要的肿瘤生物标志物和预后不良的潜在因素，可能在临床实践中得到利用。
