Centro Regionale Antidoping A. Bertinaria, Laboratorio Regionale di Tossicologia, Regione Gonzole, 10/1, Orbassano, 10043 Turin, Italy.
Forensic Sci Int. 2012 Feb 10;215(1-3):121-3. doi: 10.1016/j.forsciint.2011.01.038. Epub 2011 Mar 2.
A case of intoxication by haloperidol is reported. Haloperidol is a butyrophenone derivative commonly used in many hospital units as an antipsychotic agent. Adverse reactions due to haloperidol intoxication include drowsiness, blurred vision, extrapyramidal effects, tardive dyskinesia, tachycardia, hypotension and muscular rigidity. In August 2008, a 49 year-old female nurse started feeling various symptoms such as muscular rigidity, drowsiness and buccal dyskinesia. After 3 months, she was hospitalized for the worsening of these symptoms. Four months later, she showed once more the same symptoms. Two open water bottles from which the nurse used to drink in the hospital were confiscated and analyzed. Moreover, the nurse was asked to give a sample of her hair for executing the inherent toxicological analyses. Haloperidol was found in both bottles 1 and 2 at a concentration of 31.5 μg/mL and 43.6 μg/mL, respectively. Based on segmental hair analysis, it was deduced that the nurse consumed haloperidol in the approximate period from August 2008 to March 2009. The higher levels of haloperidol in hair were found in accordance with the periods of most severe appearance of symptoms, requiring the hospitalization of the nurse. The analysis of preservatives and excipients led us to conclude that the pharmaceutical drug was probably added to the water bottles as "Haldol 2mg/mL oral solution".
报告了一例氟哌啶醇中毒病例。氟哌啶醇是一种苯甲酰胺类衍生物，常用于许多医院科室作为抗精神病药物。氟哌啶醇中毒的不良反应包括嗜睡、视力模糊、锥体外系效应、迟发性运动障碍、心动过速、低血压和肌肉僵硬。2008 年 8 月，一名 49 岁女护士开始出现肌肉僵硬、嗜睡和口腔运动障碍等各种症状。3 个月后，她因这些症状恶化而住院。4 个月后，她再次出现同样的症状。从医院没收了两个敞口水瓶，对其进行了分析。此外，还要求护士提供头发样本进行内源性毒理学分析。在 1 号和 2 号瓶子中均发现氟哌啶醇，浓度分别为 31.5μg/mL 和 43.6μg/mL。基于分段头发分析，推断护士在 2008 年 8 月至 2009 年 3 月期间摄入了氟哌啶醇。在最严重的症状出现期间，头发中氟哌啶醇的浓度更高，这需要护士住院治疗。对防腐剂和赋形剂的分析使我们得出结论，这种药物可能作为“2mg/mL 氟哌啶醇口服液”添加到水瓶中。
