Malik Tafheem, Hasan Sheema, Pervez Shahid, Fatima Tasneem, Haleem Darakhshan Jabeen
Neurochemistry and Biochemical Neuropharmacology Unit, Department of Biochemistry, The University of Karachi, Karachi, 75270, Pakistan.
Basic Sciences, Physiology, National University of Health Sciences, Lombard, IL, USA.
Neurochem Res. 2016 Dec;41(12):3386-3398. doi: 10.1007/s11064-016-2073-z. Epub 2016 Oct 18.
The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.
帕金森症和口腔运动障碍的症状已被证明是由对其临床应用有显著影响的抗精神病药物诱发的。在本研究中，我们调查了黑种草籽油（NS）（黑孜然籽）——一种在东方国家用于治疗癫痫的传统药物——是否可以减轻氟哌啶醇（HAL）诱导的大鼠锥体外系症状（EPS）样行为。在将HAL（1毫克/千克）与NS（0.2毫升/只大鼠）联合治疗后，与对照组相比，大鼠表现出显著降低的EPS样行为，包括运动障碍和口腔运动障碍。免疫组织化学分析表明，NS减轻了尾状核和伏隔核中的星形胶质细胞增生。这些结果表明，NS可被视为抗精神病药物的辅助药物，以减少EPS样副作用。
