The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Transfus Med Rev. 2011 Jul;25(3):252-6. doi: 10.1016/j.tmrv.2011.01.003. Epub 2011 Mar 2.
In 1955, animal studies suggested that thrombocytopenia was not the initiating cause of hemorrhage. Coagulation studies in vitro revealed the correction of coagulation by fresh platelets. Platelets, freshly collected with use of nonwettable surfaces, corrected thrombocytopenia, controlled associated hemorrhage, and prevented death from bleeding. Thus, in vitro and animal studies can be misleading (bench to bedside). Careful clinical observations, elaborated by in vitro studies, which create hypotheses testable in the clinic, lead to therapeutic advances (bedside to bench and back). Platelet replacement for thrombocytopenia prevents the hemorrhagic diathesis and has been universally practiced for over 50 years.
1955 年，动物研究表明血小板减少症不是出血的起始原因。体外凝血研究显示新鲜血小板可纠正凝血。使用非润湿表面采集的新鲜血小板纠正血小板减少症，控制相关出血，并防止出血死亡。因此，体外和动物研究可能具有误导性（从实验室到病床）。通过体外研究详细阐述的仔细临床观察，提出可在临床中进行测试的假设，从而推动治疗进展（从病床到实验室再回到病床）。血小板替代治疗血小板减少症可预防出血倾向，并且已经在临床上普遍应用超过 50 年。
