硼中子俘获治疗中硼化合物和钆硼化合物的1H和10B核磁共振及磁共振成像研究
1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy.
作者信息
Bonora M, Corti M, Borsa F, Bortolussi S, Protti N, Santoro D, Stella S, Altieri S, Zonta C, Clerici A M, Cansolino L, Ferrari C, Dionigi P, Porta A, Zanoni G, Vidari G
机构信息
Physics Department A. Volta, University of Pavia, Pavia, Italy.
出版信息
Appl Radiat Isot. 2011 Dec;69(12):1702-5. doi: 10.1016/j.apradiso.2011.02.021. Epub 2011 Feb 17.
(10)B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include (1)H and (10)B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.
适用于硼中子俘获疗法（BNCT）的硼分子化合物用钆（III）顺磁性离子进行标记。新合成的分子钆 - 双丙氨酸（Gd - BPA）作为磁共振成像（MRI）中的造影剂进行研究，最终目的是绘制硼在组织中的分布情况。报告了初步的核磁共振（NMR）测量结果，其中包括动物组织中的氢（1H）和硼（10B）弛豫测量、顺磁性钆 - 双丙氨酸分子在水中的质子弛豫率及其在肿瘤活细胞中的吸收情况。
Zotero 插件