Porcari Paola, Capuani Silvia, D'Amore Emanuela, Lecce Mario, La Bella Angela, Fasano Fabrizio, Campanella Renzo, Migneco Luisa Maria, Pastore Francesco Saverio, Maraviglia Bruno
CNR-INFM SOFT, Physics Department, University of Rome "Sapienza", Rome, Italy.
Phys Med Biol. 2008 Dec 7;53(23):6979-89. doi: 10.1088/0031-9155/53/23/021. Epub 2008 Nov 12.
Boron neutron capture therapy (BNCT) is a promising binary modality used to treat malignant brain gliomas. To optimize BNCT effectiveness a non-invasive method is needed to monitor the spatial distribution of BNCT carriers in order to estimate the optimal timing for neutron irradiation. In this study, in vivo spatial distribution mapping and pharmacokinetics evaluation of the (19)F-labelled boronophenylalanine (BPA) were performed using (19)F magnetic resonance imaging ((19)F MRI) and (19)F magnetic resonance spectroscopy ((19)F MRS). Characteristic uptake of (19)F-BPA in C6 glioma showed a maximum at 2.5 h after compound infusion as confirmed by both (19)F images and (19)F spectra acquired on blood samples collected at different times after infusion. This study shows the ability of (19)F MRI to selectively map the bio-distribution of (19)F-BPA in a C6 rat glioma model, as well as providing a useful method to perform pharmacokinetics of BNCT carriers.
硼中子俘获疗法（BNCT）是一种用于治疗恶性脑胶质瘤的有前景的二元治疗方式。为了优化BNCT的疗效，需要一种非侵入性方法来监测BNCT载体的空间分布，以便估计中子辐照的最佳时机。在本研究中，使用¹⁹F磁共振成像（¹⁹F MRI）和¹⁹F磁共振波谱（¹⁹F MRS）对¹⁹F标记的硼代苯丙氨酸（BPA）进行了体内空间分布图绘制和药代动力学评估。¹⁹F-BPA在C6胶质瘤中的特征性摄取在化合物输注后2.5小时达到最大值，这通过输注后不同时间采集的血液样本的¹⁹F图像和¹⁹F光谱得到证实。本研究表明¹⁹F MRI能够在C6大鼠胶质瘤模型中选择性地绘制¹⁹F-BPA的生物分布，同时也提供了一种进行BNCT载体药代动力学研究的有用方法。
