Department of Nutritional Sciences, University of Texas at Austin, Dell Pediatric Research Institute, Austin, TX 78723, USA.
Cancer Prev Res (Phila). 2011 Mar;4(3):285-7. doi: 10.1158/1940-6207.CAPR-11-0056.
Obesity is associated with increased risk and worsened prognosis for postmenopausal breast cancer, but the underlying mechanisms remain unclear. Elegant work reported by Subbaramaiah and colleagues in this issue of the journal (beginning on page 329) adds important insights, particularly into the connections between obesity, inflammation, and aromatase via cross-talk among adipocytes, macrophages, and epithelial cells. This work provides several new molecular targets and strategies to test in model systems for preventing or controlling obesity-related breast cancer and provides a framework for studying the linkages among the complex mechanistic pathways underlying the obesity-cancer relationship.
肥胖与绝经后乳腺癌的风险增加和预后恶化有关，但潜在机制仍不清楚。在本期杂志中（从第 329 页开始），Subbaramaiah 及其同事的这项精彩工作提供了重要的见解，特别是在肥胖、炎症和芳香化酶之间的联系，涉及脂肪细胞、巨噬细胞和上皮细胞之间的串扰。这项工作为在预防或控制肥胖相关乳腺癌的模型系统中测试提供了几个新的分子靶点和策略，并为研究肥胖与癌症关系背后复杂机制途径之间的联系提供了一个框架。
