Department of Pharmaco-logy, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606-8501, Japan.
Cancer Prev Res (Phila). 2011 Mar;4(3):324-8. doi: 10.1158/1940-6207.CAPR-11-0046.
Most patients with a lethal cancer die of metastasis, the control of which deserves to be one of the most urgent missions of cancer treatment. For some subsets of colorectal cancer, metastasis is stimulated by chemokines or Notch signaling at early stages that coincide with the inflammatory phase of postoperative wound healing. This temporary phase may provide a unique opportunity for "metastasis prevention," because some novel agents have been developed that target such chemokine receptors or Notch signaling.
大多数患有致命癌症的患者死于转移，控制转移应该是癌症治疗最紧迫的任务之一。对于某些结直肠癌亚组，转移是由趋化因子或 Notch 信号在早期刺激的，这与术后伤口愈合的炎症阶段相吻合。这个暂时的阶段可能为“转移预防”提供了一个独特的机会，因为已经开发出一些针对这些趋化因子受体或 Notch 信号的新型药物。
