Julien J, Farge D, Guillemain R, Amrein C, Dreyfus G, Plouin P F, Carpentier A, Corvol P
Service d'Hypertension artérielle, Hôpital Broussais, Paris.
Presse Med. 1990;19(1):26-9.
Arterial hypertension is frequent after cardiac transplantation. Since cyclosporin was introduced its incidence has risen up to 40 to 100 per cent of the patients. Its date of onset and severity are variable. Arterial hypertension acts on the heart by increasing left ventricular hypertrophy and transplant dysfunction and on the kidney by aggravating the cyclosporin-induced renal impairment which is often present. Several mechanisms have been suggested to account for the occurrence of hypertension in these patients, including poor neurological control of blood pressure, a hypothetical haemodynamic effect and the influence of corticosteroids and cyclosporin. Cyclosporin seems to play the main role. The treatment of this iatrogenic arterial hypertension remains to be precisely determined.
心脏移植后动脉高血压很常见。自引入环孢素以来，其发病率已升至患者的40%至100%。其发病时间和严重程度各不相同。动脉高血压通过增加左心室肥厚和移植功能障碍作用于心脏，并通过加重常出现的环孢素诱导的肾功能损害作用于肾脏。已提出几种机制来解释这些患者高血压的发生，包括血压的神经控制不佳、一种假设的血流动力学效应以及皮质类固醇和环孢素的影响。环孢素似乎起主要作用。这种医源性动脉高血压的治疗仍有待精确确定。
