Mercatello A, Simplot A, Terrier A, Blanc P L, Guibaud S, Robert D
Service de Réanimation médicale, Hôpital de la Croix-Rousse, Lyon.
Presse Med. 1990 Jan 20;19(2):61-4.
Polyacrylamide gel electrophoresis of cholinesterase from cerebrospinal fluid was performed in 22 patients with Guillain-Barré syndrome. Fifteen of these patients had an abnormal cerebrospinal fluid with emergence of a second electrophoretic migration band corresponding to non-specific cholinesterase. Among 182 patients with a variety of diseases who served as controls, only one presented with this abnormality. From these data the sensitivity and specificity of cerebrospinal fluid cholinesterase electrophoresis were calculated at 68 and 99 percent respectively. The second migration band seems to appear early in the course of the disease and disappears when the patient is cured. Moreover, the occurrence of this band is correlated with the severity of the condition, as shown by a greater number of patients under artificial ventilation and by a longer stay in intensive care unit. Cerebrospinal fluid electrophoresis could be used as a prognosis factor.
对22例格林-巴利综合征患者的脑脊液胆碱酯酶进行了聚丙烯酰胺凝胶电泳。其中15例患者脑脊液异常，出现了对应非特异性胆碱酯酶的第二条电泳迁移带。在作为对照的182例患有各种疾病的患者中，只有1例出现这种异常。根据这些数据，计算出脑脊液胆碱酯酶电泳的敏感性和特异性分别为68%和99%。第二条迁移带似乎在疾病过程中早期出现，患者治愈时消失。此外，该条带的出现与病情严重程度相关，人工通气患者数量较多以及在重症监护病房停留时间较长表明了这一点。脑脊液电泳可作为一种预后因素。
