School of Life Science and Biopharmaceutical Sciences, Shenyang Pharmaceutical University, China.
Biol Pharm Bull. 2011;34(3):349-53. doi: 10.1248/bpb.34.349.
Drug combinations have more potential advantage of greater analgesia than monotherapy. By the combination of analgesics with different mechanism, potency of analgesia can be maximized while the incidence of adverse effects is minimized. This study was aimed to assess a possible interaction in the antinociceptive effects between tramadol (T) and propacetamol (P) when administered in combination against nociceptive effects induced by physical or chemical injury in mice and rats. Three series of experiments were performed. The first was to determine effects of P and T alone or in combination in the acetic acid (AA)-induced writhing test in mice. Combination of T/P (3.9/67.5, 7.8/135, 15.6/271 mg/kg, intraperitoneally (i.p.)) elicited dose-dependent antinociception. The second determined whether the antinociceptive effects of the drugs observed in a test of persistent chemical pain could be seen in a test of acute thermal pain and the back-paw licking response was tested on the hot plate. The back-paw licking latency at different times after drugs obtained with the combination (16/270, 32/540 mg/kg, i.p. T/P) was longer than the respective values obtained with the individual agents. The third was designed to compare the antinociceptive effects between the drugs, either alone or in combination in the rat tail-flicks test. Combination of T/P (5.5/96, 11/192 mg/kg i.p.) both showed effects of higher potency than T and P, respectively. The data obtained confirmed that propacetamol is able to enhance the antinociceptive activity of tramadol.
药物联合使用比单一用药具有更大的镇痛优势。通过将具有不同作用机制的镇痛药联合使用，可以最大限度地提高镇痛效果，同时最小化不良反应的发生。本研究旨在评估曲马多（T）和丙帕他莫（P）联合使用时在对抗物理或化学损伤引起的疼痛方面可能存在的相互作用。进行了三组实验。第一组是确定 P 和 T 单独或联合使用在乙酸（AA）诱导的小鼠扭体试验中的作用。T/P（3.9/67.5、7.8/135、15.6/271mg/kg，腹腔内注射）联合给药表现出剂量依赖性镇痛作用。第二组确定在持续化学性疼痛测试中观察到的药物镇痛作用是否可以在急性热痛测试中看到，并在热板上测试后爪舔舐反应。与单独使用药物相比，联合使用药物（16/270、32/540mg/kg，腹腔内注射 T/P）后不同时间的后爪舔舐潜伏期更长。第三组旨在比较单独使用或联合使用药物在大鼠尾巴闪烁试验中的镇痛效果。T/P（5.5/96、11/192mg/kg 腹腔内注射）联合使用均表现出比 T 和 P 单独使用更高的镇痛效果。获得的数据证实丙帕他莫能够增强曲马多的镇痛活性。
