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酷似结核性腹膜炎的原发性小肠自然杀伤/T细胞淋巴瘤:1例报告并文献复习

Primary small intestinal natural killer/T cell lymphoma mimicking tuberculous peritonitis: report of a case and review of the literature.

作者信息

Lin Yen-Nien, Chou Jen-Wei, Chuang Po-Heng, Cheng Ken-Sheng, Peng Cheng-Yuan, Chiang I-Ping

机构信息

Department of Internal Medicine, China Medical University Hospital, China Medical University, Taiwan.

出版信息

Intern Med. 2011;50(5):515-8. doi: 10.2169/internalmedicine.50.4435. Epub 2011 Mar 1.

Abstract

Extranodal natural killer/T cell lymphoma is very rarely encountered in clinical practice. It has a high mortality rate and very short median survival. Early diagnosis of these rare tumors, especially those originating from the small intestine, is usually difficult because of its nonspecific symptoms. Herein, we describe a case of a primary small intestinal natural killer/T cell lymphoma in a 52-year-old man who presented with abdominal fullness and weight loss. The clinical symptoms, elevation of serum levels of cancer antigen-125, and presence of ascites initially led to the suspicion of tuberculous peritonitis. Abdominal computed tomography scan demonstrated a hypodense tumor in the jejunum. Finally, the tumor was surgically confirmed to be a natural killer/T-cell lymphoma. Although aggressive chemotherapy was prescribed, the patient subsequently died of disease progression. In addition, we also review the English literature on this rare disease.

摘要

结外自然杀伤细胞/T细胞淋巴瘤在临床实践中极为罕见。它具有高死亡率和极短的中位生存期。由于这些罕见肿瘤,尤其是起源于小肠的肿瘤症状不具特异性,其早期诊断通常很困难。在此,我们描述一例52岁男性原发性小肠自然杀伤细胞/T细胞淋巴瘤病例,该患者表现为腹部胀满和体重减轻。临床症状、癌抗原125血清水平升高以及腹水的存在最初导致怀疑为结核性腹膜炎。腹部计算机断层扫描显示空肠有一个低密度肿瘤。最终,手术证实该肿瘤为自然杀伤细胞/T细胞淋巴瘤。尽管给予了积极的化疗,但患者随后因疾病进展死亡。此外,我们还回顾了关于这种罕见疾病的英文文献。

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