Yonal Ipek, Ciftcibasi Asli, Gokturk Suut, Yenerel Mustafa Nuri, Akyuz Filiz, Karaca Cetin, Demir Kadir, Besisik Fatih, Kalayoglu-Besisik Sevgi
Division of Hematology, Department of Internal Medicine, Istanbul University Medical Faculty, Istanbul, Turkey.
Case Rep Gastroenterol. 2012 Sep;6(3):803-9. doi: 10.1159/000346290. Epub 2012 Dec 22.
Involvement of the serosa may be the presenting feature in a wide and complex variety of lymphoproliferative diseases, with differing clinical outcomes covering a spectrum of benign and malignant conditions. Effusions involving peritoneal and pericardial cavities are uncommon during the course of hematological malignancies. Obstructive and/or infiltrative tumor mass or vascular leakage due to stimulation by vascular endothelial growth factor contribute to the pathogenesis. In addition to clinical findings, cytomorphology and flow cytometric immunophenotyping of the serosal fluid yield valuable information in the differential diagnosis of lymphocytic infiltrates. Herein, we describe the case of primary mantle cell lymphoma in a 75-year-old man presenting with abdominal fullness and weight loss, suggesting a gastrointestinal pathology.
浆膜受累可能是多种广泛而复杂的淋巴增殖性疾病的首发特征，其临床结局各异，涵盖一系列良性和恶性疾病。在血液系统恶性肿瘤病程中，累及腹腔和心包腔的积液并不常见。阻塞性和/或浸润性肿瘤肿块或血管内皮生长因子刺激导致的血管渗漏是其发病机制。除临床发现外，浆膜腔积液的细胞形态学和流式细胞术免疫表型分析在淋巴细胞浸润的鉴别诊断中提供了有价值的信息。在此，我们描述了一例75岁男性原发性套细胞淋巴瘤的病例，该患者以腹部胀满和体重减轻为表现，提示存在胃肠病变。
