Delluc Aurélien, Rousseau Aurélie, Delluc Céline, Le Moigne Emmanuelle, Le Gal Grégoire, Mottier Dominique, Van Dreden Patrick, Lacut Karine
Département de Médecine Interne et Pneumologie, Faculté de Médecine et des Sciences de la Santé, Université de Brest, CHU de Brest, Brest, France.
Blood Coagul Fibrinolysis. 2011 Jun;22(4):295-300. doi: 10.1097/MBC.0b013e32834512f4.
Among cancers, pancreatic cancer is known to be associated with a higher incidence of venous thromboembolism (VTE). The aim of the study was to determine the implication of circulating tissue factor (TF) in VTE related to active pancreatic cancer. One hundred and sixty-four consecutive patients who participated to the Etude des Determinants et Interactions de la Thrombose veineuse (EDITH) study between January 2005 and August 2007 for symptomatic VTE related to active pancreatic cancer (n = 8), active cancer of other location (n = 42) or classified as unprovoked (n = 114) were included. TF activity (TFa) was measured in a one-stage kinetic chromogenic method. There were no differences of median TFa levels between patients with VTE related to cancer of other type than pancreas [2.01 pmol/l range (0.05-43.92)] and patients with unprovoked VTE [1.78 pmol/l (range 0.05-63.72), P = 0.21]. Median TFa levels were higher in patients with VTE related to pancreatic cancer [12.67 pmol/l (range 0.05-112.04)] than in patients with VTE related to cancer of other type [2.01 pmol/l (range 0.05-43.92), P = 0.02]. Higher levels of circulating TFa during the course of pancreatic cancer may explain the higher incidence of VTE associated with this type of cancer.
在各类癌症中，胰腺癌与静脉血栓栓塞（VTE）的较高发病率相关。本研究的目的是确定循环组织因子（TF）在与活动性胰腺癌相关的VTE中的作用。纳入了2005年1月至2007年8月期间连续参加静脉血栓形成的决定因素和相互作用研究（EDITH）的164例患者，这些患者因与活动性胰腺癌相关的有症状VTE（n = 8）、其他部位的活动性癌症（n = 42）或归类为不明原因（n = 114）而参与研究。采用一步动力学显色法测量TF活性（TFa）。与其他类型癌症相关的VTE患者[2.01 pmol/l范围（0.05 - 43.92）]和不明原因VTE患者[1.78 pmol/l（范围0.05 - 63.72），P = 0.21]的TFa水平中位数无差异。与胰腺癌相关的VTE患者的TFa水平中位数[12.67 pmol/l（范围0.05 - 112.04）]高于与其他类型癌症相关的VTE患者[2.01 pmol/l（范围0.05 - 43.92），P = 0.02]。胰腺癌病程中循环TFa水平较高可能解释了与这种类型癌症相关的VTE发病率较高的原因。
