School of Nursing, University of Texas Health Science Center at Houston, 6901 Bertner Avenue, Houston, TX 77030, USA.
J Cardiovasc Nurs. 2011 Sep-Oct;26(5):423-9. doi: 10.1097/JCN.0b013e3182076a81.
Despite the strong evidence that depression is an independent risk factor for coronary artery disease (CAD), the underlying physiological mechanisms linking depression and CAD remain poorly understood.
This review of the literature focuses on the current understanding of the physiological effects of serotonin on depression and clotting as well as its role in CAD.
Articles for this review were identified using CINAHL, PsychINFO, and MEDLINE searches.
Results revealed that depression is an independent risk factor for CAD. Although the physiological mechanisms underlying depression and related increases in acute coronary events remain unclear, serotonin plays an important role in depression and CAD. Elevated platelet serotonin levels promote clotting, which may be a potential underlying mechanism linking depression with CAD.
This review of the literature suggests that elevated platelet serotonin levels may be associated with depression and the occurrence of major adverse coronary events. Future research should investigate if platelet serotonin levels contribute at least in part to the acute coronary events seen in patients with CAD who have elevated levels of platelet serotonin when depressed.
尽管有强烈的证据表明抑郁是冠心病（CAD）的独立危险因素，但将抑郁与 CAD 联系起来的潜在生理机制仍知之甚少。
本文献综述重点介绍了目前对血清素对抑郁和凝血的生理影响及其在 CAD 中的作用的理解。
使用 CINAHL、PsychINFO 和 MEDLINE 搜索来确定本文的综述文章。
结果表明，抑郁是 CAD 的一个独立危险因素。尽管导致抑郁和急性冠状动脉事件增加的生理机制尚不清楚，但血清素在抑郁和 CAD 中起着重要作用。血小板血清素水平升高会促进凝血，这可能是将抑郁与 CAD 联系起来的潜在机制。
对文献的综述表明，血小板血清素水平升高可能与抑郁以及主要不良冠状动脉事件的发生有关。未来的研究应调查血小板血清素水平是否至少部分导致 CAD 患者中出现的急性冠状动脉事件，这些患者在抑郁时血小板血清素水平升高。
