Hor Kan N, Baumann Rolf, Pedrizzetti Gianni, Tonti Gianni, Gottliebson William M, Taylor Michael, Benson D Woodrow, Mazur Wojciech
The Heart Institute, Cincinnati Children Hospital Medical Center (CCHMC), USA.
J Vis Exp. 2011 Feb 12(48):2356. doi: 10.3791/2356.
An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that strain is a more sensitive and earlier marker for contractile dysfunction than the frequently used parameter EF. Current technologies for CMR are time consuming and difficult to implement in clinical practice. Feature tracking is a technology that can lead to more automatization and robustness of quantitative analysis of medical images with less time consumption than comparable methods.
An automatic or manual input in a single phase serves as an initialization from which the system starts to track the displacement of individual patterns representing anatomical structures over time. The specialty of this method is that the images do not need to be manipulated in any way beforehand like e.g. tagging of CMR images.
The method is very well suited for tracking muscular tissue and with this allowing quantitative elaboration of myocardium and also blood flow.
This new method offers a robust and time saving procedure to quantify myocardial tissue and blood with displacement, velocity and deformation parameters on regular sequences of CMR imaging. It therefore can be implemented in clinical practice.
测量心肌组织应变等参数的准确实用方法具有重要临床价值,因为已有研究表明,应变是比常用参数射血分数(EF)更敏感、更早出现的收缩功能障碍标志物。当前的心脏磁共振成像(CMR)技术耗时且难以在临床实践中应用。特征跟踪技术能够使医学图像定量分析更自动化、更稳健,且比同类方法耗时更少。
在单相中进行自动或手动输入作为初始化,系统由此开始跟踪代表解剖结构的各个模式随时间的位移。该方法的特点是图像无需像例如CMR图像标记那样预先进行任何处理。
该方法非常适合跟踪肌肉组织,从而能够对心肌以及血流进行定量分析。
这种新方法提供了一种稳健且省时的程序,可通过CMR成像的常规序列,利用位移、速度和变形参数对心肌组织和血液进行量化。因此,它可在临床实践中应用。