Eckstein Jan, Körperich Hermann, Weber Oliver M, Burchert Wolfgang, Pugachov Volodymyr, Demydiuk Oleksandra, Piran Misagh
Institut für Radiologie, Nuklearmedizin und Molekulare Bildgebung, Herz- und Diabeteszentrum NRW, Universitätsklinikum der Ruhr-Universität Bochum und Universität Bielefeld Medizinische Fakultät OWL, Bad Oeynhausen, Germany.
Philips Clinical Science, Hamburg, Germany.
J Cardiovasc Transl Res. 2025 Feb;18(1):146-157. doi: 10.1007/s12265-024-10557-z. Epub 2024 Sep 18.
Right ventricular (RV) strain offers crucial diagnostic insights in cardiovascular and pulmonary disorders. Nonetheless, the absence of established reference values impedes its clinical implementation. Utilizing CMR-feature tracking, age- and gender-dependent RV strains were systematically assessed in 175 heart-healthy Caucasians, 97 females, median 32.5 years. RV global longitudinal strain (GLS) was greater in females than males (median -26.8% (-28.3;-24.1) vs. -24.4 ± 3.0%; p < 0.001), whereby radial and circumferential strain remained comparable. Age subgroups exhibited increased RV-GLS for group B (30-50 years) (-26.0 ± 3.1% vs. -24.4 ± 3.2%; p = 0.011) and group C (> 50 years) (-26.7 ± 2.3% vs. -24.4 ± 3.2%; p < 0.001) compared to group A (< 30 years). High intra-class correlation coefficients (ICC) were exhibited by intrarater variability (ICC = 0.86-0.95) and moderate levels for interrater variability (ICC = 0.50-0.73). CMR-feature tracking provides a fair quantification method of age- and gender-specific normal RV strain values, demonstrating that higher RV-GLS is linked to female gender and advancing age within a healthy Caucasian cohort.
右心室（RV）应变可为心血管和肺部疾病提供关键的诊断见解。尽管如此，缺乏既定的参考值阻碍了其临床应用。利用心脏磁共振成像（CMR）特征追踪技术，对175名心脏健康的高加索人（97名女性，年龄中位数32.5岁）进行了系统评估，分析年龄和性别依赖性右心室应变情况。女性的右心室整体纵向应变（GLS）大于男性（中位数为-26.8%（-28.3；-24.1），而男性为-24.4±3.0%；p<0.001），径向应变和周向应变则保持相当。与A组（<30岁）相比，B组（30 - 50岁）（-26.0±3.1% vs. -24.4±3.2%；p = 0.011）和C组（>50岁）（-26.7±2.3% vs. -24.4±3.2%；p<0.001）的年龄亚组右心室GLS增加。评分者内变异性表现出较高的组内相关系数（ICC）（ICC = 0.86 - 0.95），评分者间变异性为中等水平（ICC = 0.50 - 0.73）。CMR特征追踪为年龄和性别特异性的正常右心室应变值提供了一种合理的量化方法，表明在健康的高加索人群中，较高的右心室GLS与女性性别和年龄增长有关。
