α2 integrin as regulator of metastatic potential.
作者信息
Barancik Miroslav, Breier Albert
机构信息
Institute for Heart Research SAS, Bratislava, Slovakia.
出版信息
Acta Pharmacol Sin. 2011 Mar;32(3):279. doi: 10.1038/aps.2011.12.
Abstract
摘要
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α2 integrin as regulator of metastatic potential.α2整合素作为转移潜能的调节因子。
Acta Pharmacol Sin. 2011 Mar;32(3):279. doi: 10.1038/aps.2011.12.
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The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer.α₂β₁ 整合素是小鼠模型和人类癌症中的转移抑制因子。
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Trimucytin, a collagen-like snake venom protein, activates platelets independent of I-domain within alpha2 subunit of alpha2beta1 integrin.三棱蛇毒素是一种类胶原蛋白的蛇毒蛋白，可独立于α2β1整合素α2亚基中的I结构域激活血小板。
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本文引用的文献
1
The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer.α₂β₁ 整合素是小鼠模型和人类癌症中的转移抑制因子。
J Clin Invest. 2011 Jan;121(1):226-37. doi: 10.1172/JCI42328. Epub 2010 Dec 6.
2
Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.通过他汀类药物诱导阻断 Rho/Rho 相关卷曲螺旋蛋白激酶通路减少小鼠黑色素瘤的肺转移、细胞侵袭和黏附。
J Exp Clin Cancer Res. 2010 Sep 16;29(1):127. doi: 10.1186/1756-9966-29-127.
3
Important role of integrins in the cancer biology.整合素在癌症生物学中的重要作用。
Cancer Metastasis Rev. 2010 Mar;29(1):223-37. doi: 10.1007/s10555-010-9211-x.
4
PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling.PRL-3 通过 PRL-3-整合素 β1-ERK1/2 和-MMP2 信号促进 LoVo 结肠癌细胞的迁移、侵袭和转移。
Mol Cancer. 2009 Nov 24;8:110. doi: 10.1186/1476-4598-8-110.
5
Deciphering the molecular basis of breast cancer metastasis with mouse models.利用小鼠模型解析乳腺癌转移的分子基础。
Rev Endocr Metab Disord. 2007 Sep;8(3):199-213. doi: 10.1007/s11154-007-9041-5.
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