Wisneski L A
Department of Medicine, George Washington University Medical Center, Washington, DC.
Calcif Tissue Int. 1990;46 Suppl:S26-30. doi: 10.1007/BF02553290.
Salmon calcitonin has been used for the management of acute hypercalcemia for the past several years. Unlike other hypocalcemic agents, it is effective within 2 hours after first dosing. This pharmacologic agent shows peak effect at 24-48 hours and has a duration of action of 4-7 days in most cases. Its effectiveness may diminish thereafter despite continuous administration (the so-called "escape phenomenon"). Salmon calcitonin has been shown to be effective in the management of acute hypercalcemia due to a variety of causes, and, because of its low toxicity profile, it may be administered to patients with congestive heart failure or azotemia. Salmon calcitonin is also an analgesic agent in patients with pain associated with bone metastases and may be used in conjunction with other hypocalcemic agents such as mithramycin, the bisphosphonates, or gallium nitrate to prolong the clinical response to more than 1 week. Salmon calcitonin is therefore effective and safe in the management of acute hypercalcemia.
在过去几年中，鲑鱼降钙素一直用于治疗急性高钙血症。与其他降钙药物不同，它在首次给药后2小时内就有效果。这种药物在24 - 48小时达到峰值效应，在大多数情况下作用持续时间为4 - 7天。此后，尽管持续给药，其效果可能会减弱（即所谓的“逃逸现象”）。鲑鱼降钙素已被证明对各种原因引起的急性高钙血症有效，并且由于其低毒性，可用于充血性心力衰竭或氮质血症患者。鲑鱼降钙素对伴有骨转移疼痛的患者也是一种镇痛药，可与其他降钙药物如光辉霉素、双膦酸盐或硝酸镓联合使用，将临床反应延长至1周以上。因此，鲑鱼降钙素在治疗急性高钙血症方面有效且安全。
