Cardiovascular Institute, University of Pittsburgh, Scaife 560, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA.
Int J Cardiovasc Imaging. 2012 Mar;28(3):513-9. doi: 10.1007/s10554-011-9826-1. Epub 2011 Mar 4.
Some data suggests that both left ventricular (LV) systolic and diastolic function are impaired in patients with chronic pulmonary hypertension (cPH); however, a clear understanding of these specific abnormalities remains poorly characterized. LV systolic and diastolic function as well as LV myocardial performance index (MPI) were obtained and compared to total duration of mitral annular (MA) TDI systolic (MASTDId) and diastolic (MADTDId) measurements, corrected for heart rate, in 20 controls (Group I: mean 53 ± 18 years) and 30 patients (Group II: mean 55 ± 14 years) with cPH. Group II patients had relatively faster heart rates (75 ± 14 bpm vs. 63 ± 12 bpm; P < 0.003), higher LV ejection fraction (78 ± 10% vs. 68 ± 6%; P < 0.0004), similar MA systolic excursion (1.4 ± 0.2), unchanged MA TDI Ea/Aa ratios (0.86 ± 0.46 vs. 1.05 ± 0.41; P = 0.15), significantly higher LV MPI (0.98 ± 0.56 vs. 0.60 ± 0.11; P < 0.004), with a significantly shorter heart rate corrected MASTDId (251 ± 66 ms vs. 305 ± 30 ms; P < 0.001) and MADTDId (378 ± 87 ms vs. 497 ± 114 ms; P < 0.0001) than Group I. It appears that cPH shortens the total duration of both MA systolic and diastolic TDI intervals. Whether this is a result of altered LV geometry and/or confounded by the presence of relatively faster heart rates in cPH patients will require further study.
一些数据表明，慢性肺动脉高压（cPH）患者的左心室（LV）收缩和舒张功能均受损；然而，对于这些特定异常的明确认识仍描述不足。在 20 名对照组（I 组：平均年龄 53 ± 18 岁）和 30 名 cPH 患者（II 组：平均年龄 55 ± 14 岁）中，获得并比较了 LV 收缩和舒张功能以及 LV 心肌性能指数（MPI），并根据心率校正了二尖瓣环（MA）TDI 收缩（MASTDId）和舒张（MADTDId）的总测量值。与 I 组相比，II 组患者的心率相对较快（75 ± 14 bpm 比 63 ± 12 bpm；P < 0.003），LV 射血分数较高（78 ± 10% 比 68 ± 6%；P < 0.0004），MA 收缩期位移相似（1.4 ± 0.2），MA TDI Ea/Aa 比值不变（0.86 ± 0.46 比 1.05 ± 0.41；P = 0.15），LV MPI 显著升高（0.98 ± 0.56 比 0.60 ± 0.11；P < 0.004），心率校正的 MASTDId（251 ± 66 ms 比 305 ± 30 ms；P < 0.001）和 MADTDId（378 ± 87 ms 比 497 ± 114 ms；P < 0.0001）明显缩短。看来，cPH 缩短了 MA 收缩和舒张 TDI 间隔的总持续时间。这是否是 LV 几何形状改变的结果，还是由于 cPH 患者心率相对较快而产生的混杂因素，还需要进一步研究。
