由盐酸克伦特罗、雷尼替丁碱和盐酸雷尼替丁生产过程中的中间产物引起的接触性皮炎。
Contact dermatitis caused by intermediate products in the manufacture of clenbuterol, ranitidine base, and ranitidine hydrochloride.
作者信息
Romaguera C, Grimalt F, Vilaplana J
机构信息
Catédra y Escuela Profesional de Dermatología y Venereología, Facultad de Medicina, Universidad Central de Barcelona, Spain.
出版信息
Dermatol Clin. 1990 Jan;8(1):115-7.
PMID:2137389
Abstract
Clenbuterol, a beta antagonist, and ranitidine, a histamine-receptor antagonist, were associated with contact dermatitis in a chemist. The allergen in the former was an intermediate in the synthesis called beta. In the latter, intermediates and the finished base and hydrochloride were responsible.
摘要
克仑特罗（一种β受体拮抗剂）和雷尼替丁（一种组胺受体拮抗剂）在一名药剂师身上引发了接触性皮炎。前者中的过敏原是合成过程中的一种名为β的中间体。在后者中，中间体以及成品碱和盐酸盐是引发接触性皮炎的原因。
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