培养的人皮肤成纤维细胞的衰老
Aging of cultured human skin fibroblasts.
作者信息
Harley C B
机构信息
McMaster University, Hamilton, Ontario, Canada.
出版信息
Methods Mol Biol. 1990;5:25-32. doi: 10.1385/0-89603-150-0:25.
PMID:21374112
Abstract
There is substantial evidence that aging is related to the finite ability of somatic cells to divide and repair damaged tissue. Since the seminal observation of Hayflick and Moor head (1) that cultured human fibroblasts have a finite replicative lifespan, a great deal of basic biological research on aging has been based on the model of cellular senescence in vitro (2).
摘要
有大量证据表明，衰老与体细胞分裂和修复受损组织的有限能力有关。自海弗利克和穆尔黑德（1）开创性地观察到培养的人类成纤维细胞具有有限的复制寿命以来，大量关于衰老的基础生物学研究都是基于体外细胞衰老模型（2）进行的。
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